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On the sign:
THE SITE OF THIS BUILDING FORMS PART OF WHAT WAS ONCE THE PRECINCT OF THE PRIORY OF S.JOHN THE BAPTIST, HOLYWELL WITHIN A FEW YARDS STOOD FROM 1577 TO 1598 THE FIRST LONDON BUILDING SPECIALLY DEVOTED TO THE PERFORMANCE OF PLAYS AND KNOWN AS "THE THEATRE".
The sign is located where the "The Theater" in the Hackney district stood. The building is the first permanent theater in London, built in 1576. The theater employed the Lord Chamberlain’s Men group which included William Shakespeare as a playwright and even as an actor.