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On the sign:
[NEW YORK STATE SYMBOL] TANNERY BROOK TANNERS, USING HEMLOCK BARK, RAN MILLS HERE, 1830-1870. HIDES WERE BROUGHT IN SHIPS UP THE HUDSON TO KINGSTON.
The sign indicates the leather industry that was there. Also the name of the street Tannery Brook at the intersection where the sign is placed indicates that Tannery = tanners - leather processors